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Early development in many tissues is characterized by a rapid expansion in cell number.
Another cellular interaction that is important for many tissues is the re-establishment of proper innervation.
For some applications, the success of gene therapy depends on the efficiency of gene transfer into target organs, however, delivery to many tissues is limited.
One of the most prominent features of cell polarity in many tissues is the subdivision of cell membrane into apical and basolateral compartments by a belt of cell junctions.
Collagen as an important extra-cellular matrix (ECM) in many tissues is weakly antigenic and the structure of collagen sponges is highly porous with interconnected pores effective for cell infiltration and mass transfer of oxygen and nutrients.
Nrf2 knockout mice have normal embryonic development and their basal level of antioxidant status in many tissues is not different from wild type mice [11].
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Many tissues are comprised of multilayered structures for which spatial organization and inter-layers cellular communications are essential to sustain their biological functions.
Tissue specificity is a relative concept as it is dependent in part on how many tissues are used in a given study.
Though many tissues are relatively resilient in the wake of CPA treatment [25], only hematopoietic and neural stem cells have been demonstrated to contain high ALDH activity in reconstituting transplantation studies following isolation of these cell populations [26] [28].
Many tissues were still very poorly sampled, limiting the gene detectability of current EST data.
As many tissues were mixed to construct the libraries, without tagging of the cDNAs, specific-tissue sequences were searched.
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