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Following injury, many tissues have the capacity to repair the damage – and restore form and function – by deploying cellular and molecular mechanisms reminiscent of developmental programs.
Since many tissues have an anisotropic architecture, it has been proposed that aligned extracellular matrix (ECM) structures in particular could guide and support the differentiation of resident mesenchymal stem and progenitor cells (MSCs).
It has been reported that many tissues have similar DNA methylation landscapes, especially in CGIs[11], [12], [23].
However studies in many tissues have shown that the hoped for tumour selectivity is rarely achieved.
Defects in mtDNA have been found also in non-AD elderly persons; many tissues have lower respiratory function and decreased COX activity [ 56].
Genes that are evenly expressed at moderate levels in many tissues have similar T to genes that are highly expressed in only a few tissues.
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Supporting this idea is the fact that Syp is present and required in many tissues, has many downstream targets (McDermott et al., 2014) and its mechanism of action is likely to be different in different individual targets and tissues.
The wealth of genetic information on the function of circadian clocks in many tissues has provided tools to dissect the mechanisms that regulate timing on the molecular, cellular, circuit, and whole organism levels.
DACH1 is considered a tumor suppressor as loss of DACH1 expression (which is present in many tissues) has been associated with prostate, endometrial, hepatocellular, breast, lung, colorectal, and ovarian carcinoma.
The co-expression of IL-8 with IL-6, GRO-α, and GRO-β in many tissues has been well documented [ 5, 14, 19], and those genes are identified here as IL-8 related genes with an IL-8 Z-score >= 3. The GRO-γ and ENA-78 [ 14] also show a high IL-8 Z-score, although the available EST clone number for these two genes is much smaller.
The ability of stem cells to produce multiple specialized cell types along with their extensive distribution in many adult tissues have made them an attractive target for applications in tissue engineering.
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