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For the past 20-plus years, our group has studied the biosafety of human MSC engineered to produce cytokines and other factors in vivo, and we have shown sustained expression in many tissues for at least 18 months.
The distribution of the protein or mRNA of c- fos has been used to localize neuronal excitation, cellular correlates of behavior, and cell division in many tissues for over a decade [ 15- 18].
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For many tissues of humans and rodents, age-related diseases develop in a progressive, irreversible manner.
Thyroid hormone (TH) is important for the normal development of many tissues, and for the regulation of their function throughout life.
Wnts are secreted glycoproteins crucial for the development and homeostatic renewal of many tissues and for chondrocyte and osteoblast development.
Tissue interfaces are integral to the function of many tissues and for the synchronous interaction amongst tissues to create a functional whole organism.
Slc39a5 expression is restricted to many tissues important for zinc homeostasis, including the intestine, pancreas, liver and kidney and localizes to the basolateral surfaces of pancreas acinar and intestinal enterocyte cells in mice fed a zinc-adequate diet.
Successful 3D models have been developed for many tissues (reviewed in [ 12]), for example, liver where bile canaliculi was formed or breast where central lumen with production of milk protein was obtained.
COX-1 is constitutively expressed in many tissues and responsible for various physiological functions[ 7].
Another cellular interaction that is important for many tissues is the re-establishment of proper innervation.
Glucose however acts as a basic energy substrate for many tissues, and so 18F-FDG activity can be seen both physiologically and in benign conditions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com