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Macrophages can exhibit multiple phenotypes and are known inflammatory regulators in many tissues, but their phenotypes have not been characterized in IVD degeneration.
The mammalian NK2 receptor is expressed in many tissues but is enriched in the adrenal gland, the small intestine, T cells and macrophages (www.biogps.org); however, no functional studies have previously associated it with lipid metabolism.
Many tissues, but mainly the liver, metabolize the steroid hormones to physiologically inactive products that are voided mainly in the urine, though some are also eliminated via the bile and, ultimately, the feces.
Locally, cytokines play a key role in the process of repair of many tissues, but their precise role during the healing of fracture remains unknown.
Precise control of the timing and magnitude of Notch signaling is essential for the normal development of many tissues, but the feedback loops that regulate Notch are poorly understood.
It is found in many tissues, but in neurons it has especially high concentrations, and it may be up to 2% of the total protein in some brain regions.
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However, the p[actin-GAL4] (act-GAL4) [54] a driver known to be expressed in many tissues and cells (but not considered an ubiquitous driver), completely rescues lethality but, surprisingly, does not rescue the sexual dimorphism (Figure 1b).
IL-15 mRNA is expressed in many tissues [ 94], but IL-15 biosynthesis is very complex and RNA levels do not necessarily indicate protein secretion.
Others, such as GNAS/Gnas, are strongly expressed in many tissues of one but not the other species pointing towards more general expression differences between human and mouse at this locus.
Tmod1 is found in many tissues, including the brain, but has been mainly studied in erythrocytes, heart, and slow skeletal muscle.
Of note, human Sectm1 is expressed in a large variety of tissues, e.g., colon, placenta, leukocytes, kidney and stomach and we were able to identify many tissues that express Sectm1 but not Tex19, e.g., colon.
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