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"It's also dictated by how much IgE your body produces and how many tissues are affected," says Dr. Castells.
Many tissues are comprised of multilayered structures for which spatial organization and inter-layers cellular communications are essential to sustain their biological functions.
Tissue specificity is a relative concept as it is dependent in part on how many tissues are used in a given study.
Though many tissues are relatively resilient in the wake of CPA treatment [25], only hematopoietic and neural stem cells have been demonstrated to contain high ALDH activity in reconstituting transplantation studies following isolation of these cell populations [26] [28].
Many tissues are generated by stem cells that exist only transiently during development, producing terminal cells that survive for the life of the organism.
Although about 8 million ESTs have been sequenced, considering the fact that human body has over 200 tissue/cell types, many tissues are still poorly sampled.
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Another cellular interaction that is important for many tissues is the re-establishment of proper innervation.
Early development in many tissues is characterized by a rapid expansion in cell number.
For some applications, the success of gene therapy depends on the efficiency of gene transfer into target organs, however, delivery to many tissues is limited.
Collagen as an important extra-cellular matrix (ECM) in many tissues is weakly antigenic and the structure of collagen sponges is highly porous with interconnected pores effective for cell infiltration and mass transfer of oxygen and nutrients.
One of the most prominent features of cell polarity in many tissues is the subdivision of cell membrane into apical and basolateral compartments by a belt of cell junctions.
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