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It has been shown that both human and mouse pluripotent stem cells promiscuously express many tissue specific genes at low levels [7], [9], [10].
Our study detected many tissue specific genes in intestine and muscles that were previously reported by others in the same tissues (Wormbase).
We found that blood cells contained twice as many tissue specific differentially methylated positions (tDMPs) and a large number of these regions showed low DNA methylation in blood.
This detailed screening allowed a comprehensive 3D interpretation of the ethylene metabolism, identifying many tissue specific biochemical differences within the fruit.
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Satellite cells, like many tissue-specific adult stem cells, reside in a quiescent state in an instructive, anatomically defined niche.
Many tissue-specific promoters restrictedly expressed in particular cells, tissues, organs, or developmental stages have been identified (Hwang et al. 2002; Gupta et al. 2007).
First of all, the magnitude of DNA methylation changes for both types of DMRs was markedly less than many tissue-specific or cancer-related differences.
It has been proposed that many tissue-specific genes are set in a transcriptionally poised state and are expressed at low levels in ES cells [9], [29].
Active chromatin hubs (ACH) refer to the clustering of interactions between promoters and regulatory elements involved in the regulation of many tissue-specific genes [53].
With this knowledge, LRP5/6 antibodies and their alternative formats, including one-armed and bipecific antibodies, may enable finely tuned antagonism and potentiation of the many tissue-specific roles that the 19 human Wnt isoforms have evolved to perform.
On the contrary, many tissue-specific genes were not discovered to have the predicted tissue-specific A-to-I RNA editing sites, although we could not exclude the possibility that they may have other unknown tissue-specific RNA editing sites.
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