While image quality is decreased slightly when compared to a microscope objective of similar NA, many of the important tissue features are identifiable, show similarity to anatomic features seen in histology slides, and are potentially useful for diagnosis [ 27].
Regarding various animal models, the tissue features of the pig are most easily comparable to those of the humans in many aspects.
However, fibril alignment is an important feature in many tissues that needs to be monitored for effective assembly of anisotropic tissue constructs.
Indeed, lineage branching is a common feature of many tissues, both during development and regeneration [ 21- 25].
Since known clock genes are generally expressed in many tissues, this is indeed a desirable feature for candidate clock-associated genes.
Of course, because white blood cells infiltrate many tissues, cellular heterogeneity is almost certain to be a feature of any tissue measure that is used in epidemiologic study.
It has been shown that perivascular cells of arterioles and capillaries from many tissues express pericytic markers and show MSC-like and angiogenic features [ 52– 52].
One of the most attractive features of AAV vectors is their ability to support prolonged gene expression in many tissues.
Although the TNTs in tissue share many morphological features with TNTs in vitro, there are still dissimilarities that can be ascribed to the complex microenvironment in vivo.
