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One additional requirement for querying with PTBs is a parameter m, which defines how many time courses should be returned by the query.
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For instance, one can retrieve many time-course gene expression datasets from the Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/).nih.gov/geo/
The GeneChip data for Arabidopsis include many time-course experiments for external stimuli in addition to precise tissue samples collected by AtGenExpress, whereas this type of experiment may be more difficult to obtain for mammalian species.
This shape fits many experimental time courses of solid tumours, particularly in animals, where the whole natural history of the tumour can be followed.
Many transcription time course experiments reveal waves of correlated gene expression, with no standard methods to parse a large set of correlated genes into well-defined protein complexes.
The story of Mr. Armstrong's extraordinary comeback has been told many times, of course.
The Yankees have done this many times, of course, but the Red Sox have made it a similar habit.
I've spoken to Damien many times, of course I see Guy around the place.
CDK7, RBX1 and RAD23 paralogs were duplicated many times in course of Arabidopsis evolution.
We then averaged these values over the course of many live-cell imaging time courses for a given sample (n ranging between 15 to 50 per experimental group) and computed the SE for each time point.
Although in recent years many proteins involved in this system have been characterized in detail [50], [51], [52], [53], [54], the research on the dynamics of the regulation network still needs many kinetic parameters, and many transient time-course data to calibrate and validate the model.
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