Sentence examples for many target sites from inspiring English sources

The recent demonstration that variant PRC1 complexes bind to many target sites, albeit at lower levels, independently of H3K27me3 suggests that PRC1 function may be more complex than previously envisaged (Tavares et al., 2012).

We show here using many target sites, including five in y, that CRISPR-it can induce biallelic gene disruption in the soma with similar efficiency to that reported for Gantz and Bier's MCR experiment.

Looking at the distribution of all target sites for each microRNA (data not shown), this preference is due to a general bias and not caused by individual miRNAs or target mRNAs with many target sites close to the PAS.

Because mutations in target sites are evolutionarily favored only when they survive confrontation with the gene drive, using many target sites can render it statistically improbable for any one allele to survive long enough to accumulate mutations at all of the sites so long as cutting rates are high (Burt, 2003).

However, sensor equilibration time slows monotonically with increasing complementary length; and with too many target binding sites in aptamer sequence being occupied by the complementary DNA, the aptamer-target binding does not occur and no signal gain observed.

It is known that glucocorticoid receptor (GR) and NF-κB share many target gene sites (Rao et al., 2011).

However, most known miRNAs and many validated target sites are conserved across species, and we can use this information to improve our prediction accuracy.

In the absence of TnsD and TnsE, transposition mediated by a hyperactive TnsABC* occurs into many different target sites with low selectivity [26].

Indeed a degree of energetic sub-optimality may be necessary, where single miRNA has to bind many different target sites in different mRNAs.

As too many candidate target sites are involved, it is noisy and inappropriate for clinical treatment (e.g., in Figure 1E, half sites are in amyloid core of PrP).

In contrast, genes involved in more complex regulatory processes such as embryonic development have evolved longer UTRs with many microRNA target sites and perhaps also binding sites for RNA binding proteins, providing an additional layer of regulation.