It was reported that many target genes of SRF were related to calcium homeostasis42.
The RNA repeats specifically sequester or change the expression levels of several RNA-binding proteins, leading to aberrant splicing of many target genes.
Prediction of putative target genes and functional annotation implied that these altered miRNAs affect many target genes mainly involved in PI3K/Akt signaling pathway.
Experimental evidence indicates that yeast Ino80 is required for proper transcriptional regulation of many target genes (Morrison and Shen 2009), while in Drosophila, INO80 facilitates transcriptional repression of ecdysone-regulated genes during prepupal development (Neuman et al. 2014).
HIF-1α regulates many target genes including VEGF by binding to their promoters [27].
Each miRNA has the potential to mediate the expression of many target genes [19].
Each miRNA may regulate the expression of many target genes [3].
ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation.
In keeping with this we find that many target genes positively regulated by FGF signaling are also expressed in the mesoderm.
However, the pattern of differential regulation may not be enough to prevent unwanted cross-reactions between genes, since some miRNAs have too many target genes.
The result showed that each miRNA could regulate many target genes, from several to hundreds, and some development-associated genes could be regulated by many miRNAs (Table S7).
