Sentence examples for many survival pathways from inspiring English sources

Although many survival pathways are upregulated in CML, they are also active in normal stem cells.

Cancer is a multi-step processes and uses many survival pathways to prevail over normal cells.

As the hypoxic response generates many metabolic survival pathways that are essential for tumour growth, those tumours with already highly induced pathways may be more susceptible to the additional effect of vatalanib.

As explained above, the sunitinib is known to repress many cell survival pathways that are over-activated by the middle-T oncoprotein, and to present pro-apoptotic properties on tumour cells [ 30].

How each of the proteins of known function and unknown function regulate cell survival will require further study, but the diversity of proteins identified in this functional screen for protective proteins indicates that there are many intrinsic cell survival pathways.

ZA blocks protein isoprenylation, a key step in many survival and proliferation pathways.

The Hsp90 chaperone is ubiquitously activated in cancer cells and supports oncogenic survival pathways, many of which antagonize p53.

Since many key components of survival pathways are regulated by interaction with (co- chaperones [ 15], our finding is not without preco- chaperonesel insofar as we have uncovered that reduced BAG-1 expression specifically targets tumour cells to apoptosis and impairs tumorigenesis.

1– 7 However, tumors may respond to many available agents by upregulating survival pathways.

Combination therapies are especially useful in the treatment of many cancers, in part due to the ability of separate drugs to target multiple separate survival pathways upregulated in many cancer lineages [ 40].

Furthermore, mammalian cells are wired with many signaling pathways, such as developmental and survival pathways, that influence morphology in a variety of ways.