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Advances in characterisation methods and models for data interpretation are particularly important in studying organic coloring materials in the transition period corresponding to the late 19th early 20th century, when many such variants or combinations were hypothetically possible in their formulations.
Although many such variants are post-zygotically compatible (that is, inter-variant hybrids become viable and fertile), they sometimes prefer intra-variant mating to inter-variant mating.
Many such variants may appear deleterious but may nevertheless only be associated with disease because they are close to a causal mutation and not deleterious in their own right.
HTS has identified variants that cause germline Mendelian disorders (Ng et al. 2010a, b) segregating in a highly penetrant manner, expediting the discovery of many such variants (Heron et al. 2012).
Given the extensive inbreeding loops within the 2,000-monkey 2,000-monkey and its rapid expansion from 57 founders, we hypothesize that many such VRCiants that may have been carried by only a single founder could now be relatively frequent among the 721 sequenced VRC monkeys.
Finally, we also note that there are some larger intergenic regions that lack SNPs, and some sequence variation in these regions may impact gene regulation important to ear rot resistance, but we are likely to miss many such variants in our GWAS scan.
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The alternative proposition is that these diseases are caused by rare variants with large effects, and they are common because there are many such rare variants, which arise with relatively high frequency de novo.
Potentially, many such polygenic variants play a role in body weight regulation.
Many more such variants are likely to be identified in the coming years.
There is clear evidence for the involvement of several large, rare genomic copy number variants in schizophrenia, and it is likely that many more such variants will be implicated in the disorder over the coming years.
This makes the alternative hypothesis of many, highly penetrative, rare mutations in many different genes attractive; and several such variants with strong effects have been found.
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