Sentence examples for many such mutations from inspiring English sources

Many such mutations increased in frequency by natural selection until all members of the species had them.

Many such mutations, however, occur in genes that encode for proteins of unknown function, which limits our molecular understanding of, and ability to devise treatments for, human disease.

Many such mutations have not yet been identified, and even when a known mutation is found in a tumour, drugs to block its effects may be unavailable.

But scientists revealed yesterday that there are many such mutations, and that patients without them benefit.

"Over thousands of generations, many such mutations have accumulated that harm only males, while leaving females unscathed". Tom Kirkwood, professor of ageing at Newcastle University said the paper was "intriguing".

The pathogenicity and dominance status of many such mutations remain, however, unclear.

Evolved isolates have lower fitness in some alternative environments [ 4, 5, 14, 15], despite the fact that many such individual mutations can be generally beneficial across environments [ 16].

However, the observations that many carriers of such mutations are without clinical phenotype and that heterozygous mutations in these genes do not generally produce HPE in model organisms (such as mice), has led to the notion that HPE arises as a consequence of several genetic and/or environmental insults (Krauss, 2007; Ming and Muenke, 2002).

Many such disorders result from mutations in the genes that mitochondria carry.

Although such mutations share many characteristics with disease-causing mutations, they are detected within the stems of certain phylogenetic branches, survived natural selection and thus have likely been positively selected (Ruiz-Pesini et al. 2004; Ruiz-Pesini and Wallace 2006).

Walsh [ 60] has proposed that fixation of an allele with an advantageous new function, vs. becoming a pseudogene, may be the fate of many duplicate genes even when such mutations are rare, given a population that is sufficiently large.