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"Cameron and Lansley are combining disruptive top-down reorganisation with an aggressive bottom-up programme of selling as many subunits of the NHS as possible to insurers and private health interests".
Among these genes are many subunits of other OXPHOS complexes, confirming that different OXPHOS complexes have highly similar expression profiles.
It is well established that many subunits of protein complexes only acquire a stable conformation by binding to other subunits of the complex.
In line with the biased high expression of ubiquitination pathway components, we also found many subunits of the proteasome significantly overexpressed in MII oocytes and hESC.
Moreover many genes involved in oxidative phosphorylation such as many subunits of ATP syntase (ATP5J2, ATP5L, ATP5E, ATP5G1, ATP5G2) and many subunits of NADH dehydrogenase (NDUFA10, NDUFB1, NDUFB4, NDUFB8, NDUFC2, NDUFS2, NDUFS7, NDUFV1) are down-regulated, suggesting a prominent role by cetuximab in impairing mitochondrial function.
Furthermore, many subunits of NuRD are recruited to DSBs in a, at least for CHD4 and MTA1, poly(ADP ribose) polymerase (PARP -dependent manner, but surPARP -dependentot require phosphorylation of H2AX [ 128- 131].
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The essential Ctf genes are involved in a small number of cellular processes and often encode proteins that function in complexes with many subunits; for example, the kinetochore, the replication apparatus, the proteasome, and the general transcription machinery together account for a large percentage of the Ctf genes and each is composed of many essential subunits.
This presumably requires a pooling of the outputs of many subunits from earlier stages of processing.
In many subunits the occupancies of some side-chain atoms in these residues were set to zero during model refinement.
Because many subunits or components of an enzyme complex are constructed with regards to sequence similarity with other species or orthologs, validated physical protein interaction data was referred to reduce noise and redundant information here.
Detection of so many subunits seems to suggest the presence of TCP-1 that is degraded under the experimental conditions of in-gel digestion or fragmented by mass spectrometry.
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