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Redox-active metalloporphines are efficient catalysts; in the presence of a proper oxidant [17 21], they are able to oxidize many substrates, including several textile dyes, under very mild conditions.
PARP1 ADP-ribosylates many substrates including histones, regulates chromatin structure and has well-characterized roles in DNA damage responses [49].
YadA was first discovered because of its capacity to promote auto-agglutination of Y. enterocolitica and Y. pseudotuberculosis [7], [22], as well as adherence to many substrates including epithelial cells [23], [24], extracellular matrix [25], collagen [24], [25], [26], cellular but not plasma fibronectin [27], and laminin [28].
As a calcium-activated neutral protease, calpain could hydrolyze many substrates including cytoskeletal proteins.
Examples are CAS/exportin 2, which exports Impα, or CRM1 that exports many substrates, including ribosomal subunits.
However, ACE can cleave other many substrates, including bradykinin and substance P [ 17], and is probably responsible of other effects.
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Additionally, printed electronics can be fabricated on many unconventional substrates, including plastics, papers, textiles, and even rubbers, thus enabling numerous beyond-silicon applications ranging from smart packaging to electronic paper and from large-area smart wallpaper to ubiquitous wearable electronics [2].
It is found on many different substrates including sand, gravel and silt, either on the surface or semi-submerged in the sediment.
Akt regulates cell proliferation and survival through the activation and/or inactivation of many downstream substrates, including GSK-3β [35] and Forkhead (FoxO) transcription factors [36].
The serine protease, a high temperature requirement protein A2 (HTRA2), cleaved many cellular substrates including cytoskeletal proteins as well [ 9].
Many FBW7 substrates, including cyclin E, c-MYC, c-JUN, NOTCH, NF1, and MCL1, have established roles in oncogenesis (Wang et al. 2012).
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