Sentence examples for many substrates in from inspiring English sources

Inhibiting Ulp1 will increase the sumoylation level of many substrates in addition to Tec1.

Protein monoubiquitination can occur on many substrates in cells via a variety of mechanisms.

However, LY294002 has many substrates in addition to PI3K, so other inhibitors were tested.

Yeast and human nuclear RNase P are proposed to have many substrates in addition to tRNA precursors [45,48].

These chaperones are characterized by a promiscuous substrate binding and have many substrates in common (Gong et al. 2009).

Typically, however, MMPs have a poor substrate specificity and will cleave many substrates in in vitro assays.

As DNA-PKcs phosphorylate many substrates involved in NHEJ-based DNA repair, we investigated whether BCLAF1's DNA repair function could also depend on DNA-PKcs.

ATM, ATR and DNA-PKcs are not only required for activating cell-cycle checkpoints but they also phosphorylate many substrates involved in other aspects of the DDR.

The mechanisms underlying the cell-death response involve protein kinases, which phosphorylate many substrates and culminate in changes in gene expression.

Deletion of Sirt3 resulted in a marked elevation of acetylation of several mitochondrial proteins (Lombard et al, 2007), suggesting the presence of many substrates of SIRT3 in mitochondria and a broad function of SIRT3 in metabolic regulation.

That many substrates genes identified in an earlier genetic screen are longer than 2 kbps [10] may be a result of high probability of generating in-frame fusions of longer genes in the random library used for bacterial two-hybrid screenings.