Sentence examples for many substrates and from inspiring English sources

The mechanisms underlying the cell-death response involve protein kinases, which phosphorylate many substrates and culminate in changes in gene expression.

Because GSK3β modulates many substrates and signaling pathways, the mechanisms underlying its tumor suppressor or promoter activities are complex [ 25].

The lignin synthesis pathway involves many substrates and enzymes, among which the CAD enzyme catalyzes the last step in the synthesis of monolignol precursors.

Furthermore, if a reaction involves many substrates and products, the dynamic range of Δr G′○ given the physiological metabolite concentrations can be much wider.

ERK phosphorylates many substrates and the duration and intensity of its activity affects how cells respond to extracellular signals (Marshall, 1995).

The role of MSK1 in cancer progression is varied because of their many substrates and encompasses involvement in cell proliferation, transformation and inflammation [ 6, 38].

The metabolic activities of peroxisomes require that many substrates, products and cofactors have to cross the peroxisomal membrane to and from the cytosol.

However, ACE can cleave other many substrates, including bradykinin and substance P [ 17], and is probably responsible of other effects.

Exosites on the hemopexin C domain of MMPs and collagen binding fibronectin type II modules in MMP2 and -9 drive catalysis of many substrates including chemokines and collagen (reviewed by Overall, 2002).

Many substrates of PINK1 and mechanisms for PINK1-mediated Parkin activation have been postulated (Wang et al, 2011; Okatsu et al, 2012; Chen & Dorn, 2013).

Although many substrates, protein ligands, and target genes have been identified for p300/CBP, it is still unclear what fraction of the acetylome is catalyzed by p300/CBP and under what circumstances each occurs.