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Although the significance of cleavage is not well understood for many substrates, the intense study of caspase substrates has recently shed some light on these questions.
Although ATM and ATR kinases share many substrates, the different phenotypes of ATM- and ATR-deficient mice indicate that these kinases are not functionally redundant.
However, they are susceptible to brittle cracking and delamination due to high intrinsic stress and poor adhesion to many substrates.
Many substrates of enzymatic reactions are soluble in unpolar organic solvents whereas the enzymes themselves often need an aqueous environment.
It is capable of producing well-ordered 2 D nanopattern of a wide variety of materials on many substrates.
Many substrates such as silicon, sapphire, quartz, etc. have been used to fabricate ZnO films [5 7].
Many substrates can be used for the growth of diamond, such as Si, Mo, W, Ti, and Nb.
However, many substrates are vulnerable to heating [22]; thus, low-temperature synthesis of carbon nanomaterials would be attractive.
Inhibiting Ulp1 will increase the sumoylation level of many substrates in addition to Tec1.
Once activated, Akt can phosphorylate many substrates to exert its functions.
Many substrates of E3 ubiquitin ligases have been identified as being monoubiquitinylated.
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