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In this study we used the existing knowledge of omptin structure and function as a starting point for substitutional analysis, and addressed two specific questions on molecular adaptation: how many substitutions are needed and at which locations in Epo to gain a proteolytic function (plasminogen activation) and a non-proteolytic function (invasiveness) expressed by Pla.
When they are not, many substitutions are possible.
Doug Gottlieb, the point guard, said that the Gators, with their many substitutions, affected the Cowboys' rhythm.
Lavin took the blame, saying he had disrupted the continuity with too many substitutions.
Klinsmann said he purposely did not make many substitutions until after the hour mark Sunday, wanting his players to push harder in the 90-degree heat.
They were two of many substitutions on the night, but they were the ones who killed the atmosphere stone dead.
Similar(20)
Of the 61 variable sites occurring in protein-coding regions, 46 were synonymous, and 15 were nonsynonymous, with twice as many replacement substitutions found in 1st versus 2nd codon positions (10 vs. 5; table 3).
Still, in most circumstances, while many substitution reactions1 (e.g. with a primary iodide) and especially 1,4-additions2 (e.g. with α,β-unsaturated ketones) tend to be far more rapid processes, the appropriately designed substrate can often benefit considerably from a copper reagent mediated 1,2-addition, not only in terms of yield but especially with regard to diastereoselectivity.
The confidence measure is expected to truly reject (TR) as many substitution and insertion errors.
Against this, it might be argued that the many substitution failures give us reason to rethink the cases in which the substitutions go through.
The fourth method has the highest resolution of selective constraints employing as many substitution groups as necessary.
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