Many studies implicate degeneration of intervertebral discs as the cause.
Many studies implicate MMPs in the injurious process as well ALI/ARDS, which may mainly contribute to its capability of degrading all components of the extracellular matrix [60, 61].
Many studies implicate dysregulation of hypothalamic-pituitary-adrenal (HPA) axis in the etiology of major depression [ 9].
Many studies implicate the involvement of AMPK activation in triggering autophagy/mitophagy during ischemia [ 170– 172], although this is not conclusive [ 173].
Chromosome 8p is frequently lost in CRC, many studies implicate loss in later stage disease and metastases [ 13- 15], and several 8p genes have been implicated in metastasis [ 16- 19].
However, there are also many studies implicating PEA3 as a driving factor in several neoplasms, including breast, colorectal and lung and ovarian cancer (Benz et al., 1997; Davidson et al., 2003; Hiroumi et al., 2001; Liu et al., 2004).
Other miRNAs are associated with the inflammation observed in idiopathic pulmonary fibrosis (IPF) [ 12] and cystic fibrosis [ 13], and many studies implicate miRNAs in the pathogenesis of lung cancer.
As many studies implicate dysregulation of hypothalamic-pituitary-adrenal axis in the etiology of major depression and stroke, we compared the cortisol awakening response (CAR) of 28 admitted PSD patients with that of 23 age-matched caregiver controls.
Despite many studies implicating ONOO− as a key mediator of cell death following NO exposure [ 34, 35], these findings indicate that ONOO− is not a reactive intermediate in high NO generating therapies.
In fact, many studies implicate neutrophils or neutrophil-like cells, and chemokines that recruit neutrophils, as causal mediators of lung damage in mice (Keller et al., 2006; Lyadova et al., 2010; Nandi and Behar, 2011; Yang et al., 2012; Gopal et al., 2013; Major et al., 2013; Dorhoi et al., 2014; Nouailles et al., 2014).
