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Although, the conditions that trigger production of so many structural variants at a single point of time in any given cyanobacteria have not been clearly understood, few studies have shown that production of protease inhibitors from laboratory cultures is affected by light, temperature, nitrogen and phosphorus concentrations.
Many structural variants of microcystins are produced simulatenously.
The authors also identified many structural variants that could not be detected by other genomic analysis platforms.
Human chromosome 21 was chosen as a representative sample of the human genome which is small in size and for which many structural variants have been validated.
Many structural variants (SVs) are associated with genetic diseases such as psoriasis (Hollox et al., 2008) and Crohn's disease (McCarroll et al., 2008), prompting an increased interest in structural variation studies (Bashir et al., 2008; Chen et al., 2009; Hormozdiari et al., 2009; Korbel et al., 2007; 2009; Lee et al., 2008; Lee et al., 2009; Sindi et al., 2009; Tuzun et al., 2005).
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Thus, these studies point strongly to a model of schizophrenia pathogenesis that includes the effects of many different structural variants.
Many pathogenic structural variants of the human genome are known to cause facial dysmorphism.
The most abundant conjugates are the sulphates although many other structural variants are possible (Table 1).
There were many more structural variants than most in the field would have anticipated [ 5].
We find that these individuals have many more structural variants than those published, including some with the potential of disrupting gene function or regulation.
Our study shows that these individuals have many more structural variants than those published and that some of these variants have the potential to disrupt gene function or regulation.
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