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Many structural alignment methods are based on this principle.
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Heuristic algorithms have also been proposed for many variants of structural alignment problem [ 15- 23].
The distance matrix representation has been applied to many structural problems, including protein structure alignment (Caprara et al., 2004; Holm and Sander, 1993).
Structural alignment has revealed many, many examples of so-called structural superfamilies, where proteins with less than 10% identity nonetheless retain structural propinquity (Flower, 1993; Flower et al., 1993).
It is possible to perform a structural alignment on structures produced by structure prediction methods.
The two family alignments were aligned using a structural alignment of the two protein structures.
Contact: [email protected] Many structural RNAs conserve their sequence and secondary structure, and the most effective RNA homology search and alignment tools incorporate both types of conservation into their scoring systems.
Interestingly, many of the positions that were conserved in the SRP9/14 structural alignment [ 32] were occupied by the same category of amino acids in the SRP21 proteins (Fig. 5).
Found homologous structures are subsequently aligned with the target protein by a global structural alignment algorithm.
SARST [34] is an extremely rapid protein structural alignment search method which describes protein structures as one-dimensional structural strings and recruits BLAST as its alignment engine.
Duplicated domains within a structure were defined by manual observation and sequence and structural alignment.
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