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Epithelial-mesenchymal transition is induced by the integrated actions of many stimuli including transforming growth factor-β and matrix-generated signals that are also known to be implicated in inflammation, repair responses, and fibrosis.

The intrinsic pathway of apoptosis can be triggered by many stimuli including ROS.

The airway epithelial cells are known to produce ROS in response to many stimuli including weed pollens and virus [25], [44].

Tumor cells secrete VEGF in response to many stimuli including hypoxia, low pH, or cellular stress, which are prevalent in most solid tumors [5].

It has been shown that iNOS can be induced in MCs by many stimuli, including cytokines and lipopolysaccharides [31], [32]; however, this is the first study evaluating the effect of pregnancy on iNOS gene transcription in these cells.

The IL1R2 protein is expressed on B cells, monocytes/macrophages and neutrophils [30], and may be expressed in response to many stimuli, including oxygen radicals, IL-4, IL-13, and glucocorticoids [30], possibly explaining the ability of steroids to ameliorate AIED.

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In response to many different stimuli, including various hormonal, chemical, or physical agents, a chain of events is set in motion that results in prostaglandin formation and release.

[30], [31] Many environmental stimuli, including ultraviolet (UV) radiation, can generate high levels of reactive oxygen species (ROS).

The NLRP3 inflammasome has been identified as a critical signaling complex involved in activation of caspase-1 and subsequent IL-1β secretion in response to many inflammatory stimuli, including nigericin and maitotoxin [32], [41].

MAPK signaling pathway is usually activated by many extracellular stimuli, including high glucose stress.

Overexpression of BAX alone is sufficient to induce apoptosis and BAX also mediates the apoptotic signal from many death stimuli, including ultraviolet irradiation and ceramide.

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