Sentence examples for many splice variants from inspiring English sources

CD44 occurs in many splice variants and connects a variety of extracellular matrix proteins, most notably hyaluronic acid (HA), to the cell surface [33].

Another interesting example is CD44, a multi-functional cell adhesion protein for which many splice variants have been associated with the growth and progression of multiple tumor types [6], [7], [8].

Many splice variants generated from the 4 genes encoding the FGFRs and 23 FGF ligands thus far identified yield a high number of combinations ensuring a finely regulated cross-talk between epithelial and mesenchymal cells.

Third, eukaryotes often contain many splice variants within the same gene, with different agonist or antagonist function.

For instance, there are many different means of reading the genes (many splice variants) and how such genes are read depends in part on the cellular environment.

Upregulation of CD44 was verified by ELISA (as western blotting was confounded due to the many splice variants of this protein).

Three billion DNA base pairs, 50,000 genes, twice as many splice variant mRNA transcripts and a further magnification of possible protein products due to post-translational processing (let n be the number of different products) lead to n! (n factorial; e.g. 7! = 7 × 6 × 5 × 4 × 3 × 2 × 1) possible interactions.

In addition, sequencing their full-length coding regions revealed many novel splice variants.

This approach can identify many alternative splice variants if sufficient sequence reads are carried out [13], [14].

MOG, myelin/oligodendrocyte glycoprotein, has many different splice variants in humans that are not found in mice [ 17].

As discussed above, studies are complicated by the occurrence of many mRNA splice variants and possibly also by a changing glycosylation status of the protein.