Sentence examples for many splice sites from inspiring English sources

The correction of ChIP-seq input is done by subtracting the signal of each feature by the signals of ChIP-seq input, because many splice sites do not have ChIP-seq signals.

However, since the location and sequences of the polypyrimidine tract and 3′ AG have been more or less constrained for many splice sites, emergence of de novo regulatory elements between them has not been observed frequently.

We observed many novel splice sites occurring within genes, corresponding to cryptic splice sites or novel exons.

For example, in this analysis of 185/333 sequences, the aim was to identify as many putative splice sites as possible.

Such an arrangement helps in accurate splice site selection especially across large introns that may have many alternative splice sites [ 36].

Because the aim of this study was to identify as many donor splice sites as possible, both the positive and possible scores were analyzed further as "candidate" sites.

This is illustrated by the fact that typical mammalian pre-mRNAs harbor many pseudosplice sites that fit the consensus splice site sequences, but which are normally not used [ Sun and Chasin, 2000], and conversely, many functional splice sites do not conform well to the consensus splice site sequences.

58 To date, many truncating splice site mutations and missense variants for ATM have been found and associated with a relative risk of breast cancer of about 2.4.

This stabilization function explains why many 5′ splice site sequences, some of which are not completely complementary to the sequence in the U1 RNA, can still interact in a functionally significant way with the U1 snRNP.

For these genes with splice site very close to the start codon, we identified the orthologs between T. vivax and T. brucei, and in many cases the splice sites were located upstream of the annotated start codon in one of the species but downstream in the other.

Analysis of gene models predicted from assembled EST and full-length cDNA genomic alignments from rice and Arabidopsis discovered that many alternative splicing sites are separated by a small number of bases, typically four or three bases in the case of alternative donor and acceptor sites, respectively [ 12].