Sentence examples for many somatic mutations from inspiring English sources

Cancers with many somatic mutations rarely had many unusual copy numbers, and vice versa.

Here we describe a situation where the balance of these two factors is such that not one, but many, somatic mutations are detected.

Many somatic mutations are apparent in the selected cells, which are now stable in culture.

Cancer genome studies have linked many somatic mutations to CRC (Esteban-Jurado et al., 2014; Watson et al., 2013).

We do not know how many somatic mutations were present in the DFTD lineage prior to 87T and 53T divergence.

Tumors with many somatic mutations in general tend to lack CNA, while tumors with CNA have fewer somatic mutations.

While minor, these subpopulations contained many additional somatic mutations, including shared mutations in cancer genes including NOTCH1, CCND3, and BCOR.

Mutations in a number of genes have also been associated with gliomagenesis, although many are somatic mutations that do not necessarily result in expression level changes [ 11].

A conservative algorithm with high specificity may make very few incorrect predictions, but may miss many legitimate somatic mutations because of its low sensitivity.

In contrast, although allelic loss at the LKB1 locus (chromosome 19p13.3) is observed in many cancers, somatic mutations in LKB1 are relatively rare in most common tumor types, including colon [41], breast [42], ovarian [43], and brain [44] cancers.

Thus, our data may indicate that many additional somatic mutations may be shared between different patients, but reside in minor tumor subpopulations and thus go undetected at standard sequencing depths.