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Cooper (1955) showed that hyperploidy of the Y chromosome produces male sterility and many somatic defects including variegation and abnormal legs and wings.
The phenotypic effects of increasing the overall dosage of Y heterochromatin have also been demonstrated; hyperploidy of the Y chromosome produces male sterility and many somatic defects including variegation and abnormal legs and wings.
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Although many somatic gene defects have been detected in OvCa, genetic alterations unique to OvCa have been difficult to identify.
It is likely that many somatic mutations are a consequence of defects in DNA repair and maintenance (Slupphaug et al, 2003; Barnes and Lindahl, 2005) or past exposure to mutagens (Luch, 2005) or both of these phenomena.
When this deletion is present, it is observed in many somatic cells and is often associated with structural defects such as microcephaly, micropthalmia and several skeletal and genitourinary abnormalities3,4.
A single genetic locus is unlikely to predispose many somatic cells to tumour formation unless a fundamental molecular defect for example, related to DNA repair is present.
Cancers with many somatic mutations rarely had many unusual copy numbers, and vice versa.
High throughput sequencing has led to the discovery of many somatic rearrangements that initiate or promote cancer development.
No gross somatic defects were observed in adult Tex19.1−/− mice.
The reporter expression is seen in many somatic FCs in the abdomen.
Its depletion causes meiotic and somatic defects in Arabidopsis and progressive motor impairment accompanied by several cell deficiencies in patients with ataxia telangiectasia (AT).
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