Cancers with many somatic mutations rarely had many unusual copy numbers, and vice versa.
High throughput sequencing has led to the discovery of many somatic rearrangements that initiate or promote cancer development.
Our findings demonstrate that absence of H3K27me3 from the sperm-inherited genome results in the derepression of many somatic genes, especially neuronal genes, predominantly from sperm-inherited alleles.
A single genetic locus is unlikely to predispose many somatic cells to tumour formation unless a fundamental molecular defect for example, related to DNA repair is present.
In duf −3.8 kb Gal4 no expression was detected in LT2, LT4 and VO2 somatic FCs but there was strong expression in other Kr positive somatic FCs.
duf −3.8 kb lacZ is expressed strongly in 6 Kr positive somatic FCs but very weakly in LT2, LT4 and VO2 somatic FCs.
These transcription factors mark different somatic muscles as follows: Kr is expressed in DA1, DO1, LL1, LT2, LT4, VL3, VA2, VO2 and VO4 somatic FCs (Figure 3B).
Deletions from the proximal end such as duf −7.9−3.8 kb Gal4, duf −9.8−3.8 kb Gal4 and duf −8.2−0.6 kb Gal4 all show consistent and strong expression patterns in circular visceral muscle FCs and very few somatic FCs in the embryo.
duf −1.5 kb lacZ also shows strong expression in ventral and dorsal clusters of somatic FCs in the abdominal segments (arrowheads, Figure 2, C and C').
duf −4.6 kb lacZ (data not shown) and duf −5.1 kb lacZ are expressed weakly in LT2, not detectable in VA2 but strongly in all other Kr positive somatic FCs.
