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Many small molecules that induce autophagy are now available.
Actin is a globular protein that polymerizes (joins together many small molecules) to form long filaments.
Although many small molecules have been identified as allosteric inhibitors of NS5B, very few are active in clinical applications.
This pathway can synthesize many small molecules and strengthen the cell wall by depositing callose and lignin, which may inhibit the pathogenic bacteria growth and spread in plants34.
Many small molecules that stimulate oligodendrocyte formation act not through their canonical pathways but by inhibiting enzymes within the cholesterol biosynthesis pathway and thereby inducing the accumulation of 8,9-unsaturated sterols.
Polymerization (the repetitive joining of many small molecules into larger ones) of ethylene gives polyethylene, a polymer having many uses, particularly in the production of packaging films, wire coatings, and squeeze bottles.
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There is compelling evidence that cellular DNA is the target of many small molecule anticancer agents.
Large scale screening of libraries consisting of natural and small molecules led to the identification of many small molecule inhibitors repressing Wnt/β-Catenin signaling.
Together, they are able to reduce the efficacy and modify the pharmacological properties of anti-cancer agents, including many small molecule tyrosine kinase inhibitors (TKIs).
However, the oral uptake of many small molecule drugs and biotherapeutics is limited by various physiological barriers, and, as a result, drugs suffer from issues with low solubility, low permeability, and degradation following oral administration.
Correspondingly, many small molecule compounds have been designed to modulate the activity of histone demethylases and DNA methyltransferases, and some of them have been developed into therapeutic drugs or put into clinical trials.
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