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This variation confirms that both AGO fusion proteins are concentrated at many small foci.
The many small foci of AGO proteins in the cytoplasm are good candidates for sites of repression.
Using high resolution confocal microscopy and detection either by immunofluorescence in fixed ovaries or live imaging of an AGO1 GFP fusion, we find that AGO1 is present in many small foci rather than being uniformly dispersed throughout the cytoplasm.
At higher magnification, the distribution of both AGO1 GFP and AGO2 GFP can be seen to be punctate, with the proteins appearing in many small foci (Fig. 3B,C).
In leptotene spermatocytes, many small foci are present throughout the nucleus.
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By contrast, the DNA in ∆ recB cells appeared fragmented as many small DAPI foci dispersed throughout the cells.
In spermatocytes of the zebrafinch, many small MLH1 foci form aggregates around SYCP3 filaments of different chromosomes already at early zygotene.
Many small firms focus on job boards, with lower advertising costs and a broad range of job sectors from general to niche.
Concerns center on the inability of a national scale program to adequately support a diverse industry with many small producers focused on local markets.
There were many small, less-intense foci, but modally 4-10 larger foci in most nuclei.
In the present case, the tumor was consisted of many small scattered tumor foci even in the central collapsed area (Fig. 1b); thus, the appearance of the tumor on HRCT might have a possibility to be p-GGN.
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