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Unfortunately, traditional statistical tools are ill-suited for analyzing high dimensional datasets with many small effects.
"There's not really great consistent evidence [for any one cause] and that's probably due to the fact that it's such a complicated problem that's caused by many small effects that all together make you miserable," he added.
From our results, we can suggest that a substantial amount of the genetic contribution to intelligence differences comes from many, many small effects from genetic variants that are in linked with common variants (SNPs).
We consider direct sequencing to be more reliable here, as phenotypic mutation accumulation misses many small effects [ 87, 48].
For both traits the BLUP analysis estimated many small effects, whereas the RMLV analysis estimated a few large effects and many effects near zero.
It is believed that gamma distributions are a characteristic of a trait that has many small effects QTL but few loci causing most of the genetic variation.
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Third, many small effect mutations can together have a large effect on polygenic traits.
Predictability alone therefore not an unequivocal argument for many small effect mutations.
(B ) Conversely, if adaptation is due to many small effect mutations, the successful lineage (thick) is always among the most fit individuals.
Our fitness inference framework is based on the selection-biased diffusion model that assumes evolution proceeds via accumulation of many small effect mutations.
Our QTL analysis indicated that FD is a polygenic trait controlled by many small effect QTLs, of which only a subset are stable across years.
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