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Predictability alone therefore not an unequivocal argument for many small effect mutations.
Third, many small effect mutations can together have a large effect on polygenic traits.
(B ) Conversely, if adaptation is due to many small effect mutations, the successful lineage (thick) is always among the most fit individuals.
Our fitness inference framework is based on the selection-biased diffusion model that assumes evolution proceeds via accumulation of many small effect mutations.
Our QTL analysis indicated that FD is a polygenic trait controlled by many small effect QTLs, of which only a subset are stable across years.
Empirical studies (Xu 2007; Li and Sillanpää 2012) have shown that LASSO-CV tends to select many small effect markers in addition to the major QTL.
Similar(46)
Unfortunately, traditional statistical tools are ill-suited for analyzing high dimensional datasets with many small effects.
We consider direct sequencing to be more reliable here, as phenotypic mutation accumulation misses many small effects [ 87, 48].
For both traits the BLUP analysis estimated many small effects, whereas the RMLV analysis estimated a few large effects and many effects near zero.
It is believed that gamma distributions are a characteristic of a trait that has many small effects QTL but few loci causing most of the genetic variation.
The familial structure tends to be more informative in traits with many small effects and high heritability, as in these cases the similarity at the genotyped SNPs tends to be more informative of the (potentially unobserved) causal loci in related individuals compared with unrelated individuals.
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