After all, for many single loci sequenced in conventional phylogenetic analysis, most sites are conserved and uninformative.
Furthermore, mitochondrial DNA is more likely than many single nuclear sequence loci to reflect historical population affinities given the former's smaller effective population size.
Despite these variations between the mouse and human genomes, Cheng et al.6 show that many single-nucleotide sequence differences that have been associated with diseases in genome-wide association studies in humans are localized to orthologous regions of the mouse genome that have modifications that mark active chromatin.
Prefractionation of the peptides by use of strong cation exchange chromatography results in a 2-fold increase in the number of peptide assignments (17% of the peptide library); however, the majority of the unique peptide masses were assigned to single sequences, indicating that many peptide isomers were not separated.
Many single nucleotide polymorphism (SNP) sites were detected among COI sequences of nine seahorse species.
Such barcodes allow researchers to analyze digital tags from transcriptomes of many samples in a single sequencing run by simply pooling the libraries.
As expected for a short single sequence, many CAGA boxes were predicted in most of the 39 genes, irrespective of the presence of ASEs.
DNA barcoding methods make high-density genotyping cost-effective by multiplexing many individual genomes into a single sequencing library (Baird et al. 2008; Andolfatto et al. 2011).
Thus, we score each distinct IgH sequence containing the indicated N nucleotide insertions as a single sequence, regardless how many times this sequence was detected.
To minimize the impact of self-replenishment on the N-addition distribution profile, and hence to weight the repertoire for de novo generated IgH sequences for B-1a cells, we collected normalized data that counts each distinct IgH sequence containing indicated N nucleotide insertions as a single sequence, regardless how many times this sequence was detected.
