In a cross between such heterozygous parents, many single-dose polymorphic markers will amplify in one parent but will be absent in the other; therefore, they are expected to segregate in a 1 l ratio in their progeny (Grattapaglia and Sederoff 1994).
Single markers or low numbers of markers are left normal.
Many single-nucleotide polymorphism (SNP) markers have been identified and scored on a maize diversity panel (composed of 302 inbred line) that represents the diversity available in public breeding sector around the world [ 49, 50].
However, given that our multi-locus method is more powerful than single marker analysis under many genotypic configurations, it is possible that our method is more sensitive to cryptic relatedness or residual population stratification than is single marker analysis.
Secondly, carrying out thousands of dependent single marker tests tends to produce many false positives.
The characteristic of a single marker are usually reported in many articles, and an emergent task is the integration of the effect sizes of markers (i.e., sensitivity and specificity of a diagnostic/screening marker or the hazard ratio (HR) and its variance, SE or CI as a prognostic/monitoring marker) using SRMA.
Moreover, in many cases, scientists are trying to find not a single marker but several that could be used together to get a more accurate reading.
Moreover, they restricted the questions to a single marker (CD150) to avoid having too many different experimental arms.
(B) Multipoint detection : Many disease types are not well defined by a single marker and require the coexistence of a panel of markers to ensure reliability of measurement (Vafadar-Isfahani et al., 2012 ).
The use of an aggregate marker such as the diabetes marker (Table 2), which is less sensitive to variability of spot measurements in individual variables, captures many more potential associations than either method using a single marker; but prudent follow-up should include consideration of the associations seen with each marker individually.
