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Although many single genes are well-known to be involved in the biological machinery of resistance against platinum agents, no approved predictive biomarker is yet available.
Hence, due to the methods employed in this study we have succeeded in identifying many single genes, and small blocks of genes, located in between genomic islands/islets as absent/divergent.
Using mutation load for prediction/prognosis enables easy, quantitative estimation, and may have a greater global impact on breast cancer clinical outcomes than many single genes which are currently considered important.
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However, extensive screening have failed to identify many single gene variants of large effect.
Concatenation of (many) single gene-alignments may effectively correct for the erroneous phylogenetic signal contained in single genes, and it has been shown that even genes producing incongruent phylogenies are useful in multi-gene alignments, as they may provide additional information for resolving at least some short branches.
PCD is also a genetically heterogeneous disorder with many single gene mutations leading to similar clinical phenotypes.
For an improved understanding of many single gene disorders, targeted enrichment can help produce a catalog of rare causative mutations by deeply sequencing genomic loci of a large number of patients.
Arabidopsis thaliana and Caenorhabditis elegans were chosen as representatives for plants and nematodes, respectively, because they are designated model species and many single gene studies as well as whole transcriptome analyses have been performed.
Many single-gene diseases, caused by mutant alleles of a single gene, have been discovered.
Many single-gene knockouts result in increased phenotypic (e.g., morphological) variability among the mutant's offspring.
Moreover, epigenetic mechanisms of gene regulation may cause many single-gene, as well as poly-gene, genetic diseases.
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