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For example, with an FDR of 10% we detect over 10 times as many significant genes in males as in females (Figure 1b).
Subsequently, chromosomes 1, 2, and 17 were determined to have many significant genes.
Many significant genes that map to these regions had previously been associated with specific histologies [ 2- 5].
There still could be too many significant genes in a model, which could make the model estimate unstable.
Many significant genes in EC played central roles in regulating the MAP kinase/ERKs signaling pathway and affected cell division, differentiation, and secretion.
Many significant genes at the 3q26.2 q29 regions previously linked to a specific histology, such as EVI1, MDS1, PIK3CA and TP73L, were observed in SCC (P < 0.05).
Similar(50)
PDK4, pyruvate dehydrogenase kinase, isozyme 4a, well known to be associated with diabetes (Cadoudal et al., 2008; Kim et al., 2006), is another gene that also appears in many significant gene sets.
The comparison of the three originally isogenic strains BR-F, BR-S and BR-RF revealed many significant gene expression and phenotypic differences, but only a few of them seem to be related to the formation of structured biofilm colonies.
However, there were many highly significant genes showing novel isoforms in our data that were not previously associated with cancer.
Hence, a multiple-knockouts analysis finds many more significant genes when examining individual tasks, than a single-knockout analysis.
The genes identified in the original analysis (Desai et al., 2011) were largely identified in our analysis, although our analysis provided many more significant genes.
Related(20)
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