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Thus zinc is an essential prerequisite for the progress of many signalling processes in eukaryotes and deregulation of its metabolism can induce DNA damage and cancer risk [30].
On the basis of these findings and general considerations, it is currently almost impossible for many signalling processes to become readily obvious as being truly regulated.
Trypsin homologue YP_434226.1 (see above) was also found associated with an SCP domain (C-terminal to trypsin and PPC domains) likely to have a calcium chelating function and is involved in many signalling processes [ 73].
The last decade has witnessed an unprecedented explosion of biological knowledge and large data sets acquired for many signalling processes at the cellular level, largely due to the development of sophisticated and high-throughput biochemical techniques in proteomics and other omics.
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Around 40% of the genes (159 IDs), which had an altered expression in the wild-type, were regulated in the nin mutant (Figure 2A and Folder S3), and many of the signalling processes induced by M. loti in the wild-type were also induced in nin mutants (Figure 2B and Folder S3).
These included signalling processes (intracellular signalling cascade, RAS protein signal transduction, small GTPase mediated signal transduction), transport (nucleocytoplasmic transport, nuclear transport, intracellular protein transport) and anti-apoptosis.
Such ultrasensitivity, as characterised by a sigmoid signal/response curve, is an important feature of many signalling pathways and cellular decision making processes.
uPAR has been reported to associate with many signalling molecules and to mediate signal transduction (Aguirre Ghiso et al, 1999).
Second, a change in the UE state between idle and connected states causes an exchange that requires many signalling messages between network entities as well as signalling messages that need to be processed by the MME.
Caveolae are distinct lipid microdomains involved in the compartmentalization of many signalling molecules, including eNOS, and facilitating signal transduction.
Many signalling pathways converge upon transcription factors, which integrate signalling information for the transcriptional regulation of downstream target genes.
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