Chao, M. V. Neurotrophins and their receptors: a convergence point for many signalling pathways.
The most abundant GO pathways include many signalling pathways (e.g., Wnt, TGF-beta, cadherin signalling, integrin signalling; Supplementary Data 4).
Besides EMT, which was the most enriched in all signatures, many signalling pathways relevant for MaSC biology were significantly enriched, including Notch, which is a direct miR-34a target, p53, mTORC, and the Wnt/beta-catenin signalling pathway (Fig. 4j).
Consistent with its pleiotropic role, leptin interacts with many signalling pathways including those involving NO [64].
Many signalling pathways have been implicated in this process, including PI3 kinases and Rho GTPases.
As ER stress alters many signalling pathways, we cannot exclude the possibility that other pathways altered by ER stress also contribute to the change of AKT phosphorylation.
The development of the Drosophila compound eye is a complex process involving the interplay of many signalling pathways (reviewed in [1]).
Many signalling pathways are thought to control CREB phosphorylation status, depending on cell and physiopathological status.
The spindle assembly checkpoint requires the coordination between many signalling pathways.
Ultimately, many signalling pathways that determine cell fate converge at the Bcl-2 family.
These results indicated that the mechanisms of canstatin are involved in many signalling pathways.
