Sentence examples for many signalling networks from inspiring English sources

Mathematical modelling has been used to analyse and understand many signalling networks.

As with many signalling networks, the key question now is how the alternative binding interactions are managed.

The ability of carcinoma cells to transition from an adherent, epithelial phenotype to a migratory, mesenchymal phenotype (the epithelial-to-mesenchymal transition, EMT) is well established, as are many signalling networks responsible for this transformation (Kalluri & Weinberg, 2009).

Perfect adaptation is a critical feature of many cellular signalling networks - it allows a cell to respond to a stimulus, but to re-sensitize itself so that further increases in stimulus can be detected.

Second, a change in the UE state between idle and connected states causes an exchange that requires many signalling messages between network entities as well as signalling messages that need to be processed by the MME.

Furthermore, systems biology means that intracellular signalling networks have many redundant and compensatory pathways, making targeting of any single component potentially a futile approach.

This ensemble network has many features expected of complex signalling networks assembled from high-throughput data: a power law distribution of both node degree and edge annotations, and topological features of a "bow tie" architecture in which diverse pathways converge on a highly conserved set of enzymatic cascades focused around PI3K/AKT, MAPK/ERK, JAK/STAT, NFκB, and apoptotic signaling.

It is increasingly being recognized that a conceptual basis for studying spatial signal transduction in signalling networks is necessary.

To our current knowledge, c-Jun remains at the centre stage of a complex molecular network, c-Jun interacting with many signalling pathways, some of which are yet to be discovered.

The tight spacing of control sites on the eNOS surface paints a picture of a system in which eNOS is at the junction of many signalling pathways and is an active node in the resulting network.

Many of these paths are inconsistent with well-established mechanistic features of signalling networks, such as a requirement for a transmembrane receptor in sensing extracellular ligands.