Exact(1)
Many signalling components (kinase, phosphatase, calmodulin, and calcium signalling), transcription factors (WRKY and MYB), and disease resistance proteins were repressed, supporting the view that suppression of endogenous signals is required to establish the compatible interaction [ 5].
Similar(59)
Moreover, H2O2 is able to modulate the activities of many other signalling components (thus relay signals) and intercalate in a number of signalling cascades with different biological outcomes, including the one that leads to its own synthesis (Fig. 2).
Many of the signalling components of the mTOR cascade are frequently deregulated in a wide variety of cancers and other human diseases (9).
Since many of the signalling components are produced only in isolated parts of the follicle, with some diffusing and others being cell-bound, also spatio-temporal signalling gradients can be expected to emerge that may play an important role and may explain some of the counterintuitive data.
The Grb10 adaptor protein is capable of interacting with many receptors and downstream signalling components, including mTOR [ 45– 45].
Invariably, it has been shown that NO modifies the activity of enzymes and some key signalling components, and many have suggested an integration between NO/GSNO SA ROS-associated eveNO/GSNO SA ROS-associated
Rafts are dynamic membrane regions that cluster together components of many signalling cascades known to be altered in cancer [ 12, 13].
Drosophila has provided many insights about the TGF-β signalling components and their molecular mechanisms [3], [4].
uPAR has been reported to associate with many signalling molecules and to mediate signal transduction (Aguirre Ghiso et al, 1999).
Caveolae are distinct lipid microdomains involved in the compartmentalization of many signalling molecules, including eNOS, and facilitating signal transduction.
The association of the signalling components with the scaffold protein allows signal channelling to a specific outcome.
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