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During consensus mapping, the first step is also building skeleton maps for each dataset, but now we should retain as many shared markers as possible.
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Ideally, all shared markers would be colinear, but in many situations discrepancies needed to be resolved.
Three gene finding studies showed that gay brothers share genetic markers on the X chromosome; the most recent study also found shared markers on chromosome 8.
By analyzing genetic markers called amplified fragment-length polymorphisms, the researchers could tell whether a Svalbard sample had, say, Russian ancestry, because of the many markers shared between that sample and a Russian one.
In CML patients, analysis of MDSC expansion is complicated by the fact that CML cells share many markers with MDSCs.
Furthermore, many cancers share the same markers e.g. CEA, CA19-9, trandferrin alpha1-antitrypsinpsin [ 40, 42, 64].
Depletion of Th17 cells by targeting specific surface proteins may be difficult as Th17 cells share many surface markers with other T-cell subsets.
Phenotypically, feline and human MSCs shared surface markers, and lacked hematopoietic markers, with similar morphology.
Across the region many share similar experiences.
Both EPCs and hematopoietic stem cells share many surface marker antigens and are descended from precursor hemangioblasts during embryonic development [ 28, 29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com