Sentence examples for many sequencing studies from inspiring English sources

Many sequencing studies are now underway to identify the genetic causes for both Mendelian and complex traits.

Currently, many sequencing studies are underway, resulting in enormous amounts of detected variants.

Recently, a study [ 46] showed that misannotations of rDNA genes can generate false positive matches in many sequencing studies of both prokaryotes and eukaryotes as these misannotations have been propagated in databases such as GenBank and SwissProt.

In the present study, our first goal is to explore the impact of sampling on demographic inferences within two empirical datasets with divergent population structure and history and with a number of loci in the same range as many sequence studies on natural populations of nonmodel organisms (13 16 loci).

High throughput 454 sequencing which generates longer reads has been widely used in many transcriptome sequencing studies in non-model species previously [ 48, 49].

Given that the proportion of phenotype variance explained is a function of allele frequency and effect size [approximated as β × (2 pq ], limitations in sample size mean that many current sequencing studies are powered to detect only those single low-frequency variants that explain substantially more phenotypic variance than single common SNPs.

Motivation: The clustering of expressed sequence tags (ESTs) is a crucial step in many sequence analysis studies that require a high level of redundancy.

Bearing these technological challenges in mind will significantly improve many large-scale sequencing studies and will - in the long term - result in a more reliable prediction of individual cancer therapies.

Because larger sample sizes are required to detect rare variants than common variants (with similar effect sizes), combining evidence from many sources is necessary for sequencing studies.

Genome-wide sequencing studies in many organisms have revealed that protein-coding mRNAs are augmented by a multitude of non-protein coding RNAs (ncRNAs), many produced from regions of the genome traditionally considered to be transcriptionally silent (The ENCODE Project Consortium, 2012; Bertone et al., 2004; Cheng et al., 2005; David et al., 2006; Birney et al., 2007).

It has become clear from large-scale sequencing studies that many individuals in the general population harbour large numbers of potentially disadvantageous variants without suffering any obvious ill effects (The 1000 Genomes Project Consortium 2010; MacArthur et al. 2012; Xue et al. 2012; Shen et al. 2013a).