However, this would not explain the relatively low degree of promiscuity observed for active compounds from screening libraries, many of which are extensively tested.
Fragment screening is an alternative method to conventional high-throughput screening using small compounds of ~250 Da, which have many more desirable properties for the discovery of lead compounds than ~350 Da compounds used in conventional screening libraries.
SA2 was initially designed to manage and analyse screening libraries.
In addition, the use of the same library for many screens permits the identification of fragments that are highly connected and thus are potential "false positives" [ 33].
Many factors should be considered while selecting an optimal screening library.
While there are many complementary strategies to expand and enhance an existing screening library, one among several that we considered was the role of randomness in molecular assembly at the atomic level.
Many libraries are currently available from different vendors yet the selection of the optimal screening library for a specific project is challenging.
But Welker catches many, many screens.
L.T.M. and A.I.L. compiled the phosphatase screening library.
