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These results imply that, among the many regulatory inputs to mTORC1, the amino acid pathway is particularly important in controlling TFEB activity and plays not only a permissive but also an instructive role.
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Although well known as 'leak' channels that are constitutively open at rest, many K2Ps are polymodal and respond to a wide range of diverse regulatory inputs that include extracellular and intracellular pH, temperature, membrane stretch, polyunsaturated fatty acids, volatile anaesthetics, and noxious chemicals (Honore, 2007; Enyedi and Czirjak, 2010).
Recent experimental work showed that the information encoded by many regulatory control elements, namely specific DNA-binding transcription factors (TFs) and their cofactors, epigenetic marks, microRNAs and other input signals, is integrated to orchestrate the expression patterns of genes in a context-dependent manner in time and space (Spitz and Furlong, 2012).
Although at the cellular level many developmental decisions can be broken down to a simple choice between two outcomes, it is clear that there are multiple regulatory inputs into that decision (reviewed by [ 1]).
The same applies to many regulatory and fiscal measures.
Many regulatory departments have overlapping mandates.
In many regulatory jurisdictions these units can be employed without requiring specific regulatory consents.
These systems function by processing diverse regulatory inputs, generating novel regulatory outputs.
However, the same fundamental concepts apply in many regulatory contexts.
Public hearings are required in many regulatory regimes all over the world.
Lean stability, while currently in scope of many regulatory guidances represents a new and evolving concept.
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