Sentence examples for many regulatory elements from inspiring English sources

Furthermore, despite the different primary sequences of many regulatory elements, the basic reciprocal regulatory networks among transcription factors are evolutionarily conserved between mice and humans5.

The MT3 promoter presents many regulatory elements, such us MRE (Metal Responsive Element) that allows MT induction by metal cations through MTF1 transcription factor and GRE (Glucocorticoid Responsive Element) for glucocorticoids induction.

The 5' LTR contains many regulatory elements, most of which are within U3 [ 21, 22].

This implies that many regulatory elements are not conserved in rodents.

In line with this, CGIs have been shown to harbor many regulatory elements and are active regulators for transcription [ 34].

Nevertheless, the noncoding regions are not junk DNA but contain many regulatory elements essential for gene expression as well.

The understanding of this combinatorial interplay requires a paradigm shift from single key players to the coupled activity of many regulatory control elements.

Recent experimental work showed that the information encoded by many regulatory control elements, namely specific DNA-binding transcription factors (TFs) and their cofactors, epigenetic marks, microRNAs and other input signals, is integrated to orchestrate the expression patterns of genes in a context-dependent manner in time and space (Spitz and Furlong, 2012).

In addition to the promoter, many other regulatory elements are required for spatiotemporally and quantitatively correct gene expression.

This was not an unexpected result, as many key regulatory elements of signalling pathways in mammalian cells are regulated by non-transcriptional controls [34], [35], and so do not appear as DE genes within microarray datasets.

Comparisons of human and rodent genomes, thought to have split ∼100 MYA [78], yield many novel regulatory elements, while extending divergence to mammals and birds (∼310 MYA [79] [80]) causes a precipitous drop off in the ability to detect motifs [81] [82].