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The rat small RNA inventory described here will also be important for understanding human disease, since many rat models were selected to reflect clinical symptoms [ 33].
Furthermore, although the protective effect of parity has been well characterized in many rat models of chemical carcinogenesis, these studies have only been performed in three strains of mouse [ 16, 17].
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Furthermore, many rat disease models are available.
Many mouse and rat models of ciliopathies have been described (Harris, 2007; Hildebrandt et al., 2011; Menezes and Germino, 2009).
Among the many strains of rat models SHR is generally used, even though it represents only a particular type of hypertension [ 35].
There are many well-characterized rat models of cardiac disease, and the organization of myocytes and perimysial collagen in the normal rat heart is qualitatively similar to that observed in the dog (27) and pig (13).
For many years, tumor-susceptible rat models were the mainstay of this experimental effort; however, there is a growing body of evidence suggesting that several strains of mice may also be appropriate models for these studies.
Many studies in humans and in rat models have been conducted to clarify the relationship between oxidative stress and antioxidants in the liver.
In this context, transgenesis protocols based on Sleeping Beauty or piggyBac transposition providing the transposase in the form of mRNA have been validated in many eukaryotic species, including mouse and rat models [ 7- 9], and in cultured human cells [ 10].
Database URL: http://rgd.mcw.edu Rat models have been used for many decades to study physiological and pathological processes.
Furthermore, there have been many recent fracture healing studies that have used rat models of indirect fracture healing.
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