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Many proteins only associate with chromatin under specific physiological conditions.
If I already have a list of over-predicted protein-protein interactions with many proteins only indirectly affected by the infection process,what do I learn from the domain or sequence property distribution in this?
Proteins consist of an elaborate arrangement of interior folds that collapse into a final thermodynamically stable structure and, for many proteins, only a modest free-energy gain (generally only −3 to −7 kcal/mol) (Lindquist and Kelly, 2011) is associated with correct folding of a protein compared with its innumerable potential misfolded states.
Next, we estimated for how many proteins of the 15 apicomplexan species (against SwissProt database) all the three matrices were able to identify orthologs, any two matrices were able to identify orthologs and for how many proteins, only one matrix was able to identify orthologs.
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However, many proteins exclusively occur in eukaryotes, and only a few of the latter are thermophilic (defined as having an optimal growth temperature [OGT] above 50°C; [ 2].
Providing that mainly the function of upregulated proteins contributes to the observed macroscopic effect, we wanted to answer the following questions: (1) How many (and which) proteins are only induced by a special TTP dose, particularly by 120 s? (2) How many proteins are only induced by one time span?
Because lysine is part of numerous proteins throughout the body, the finding suggests that cocaine has the potential to modify many proteins, not only albumin.
Many proteins are only functional after assembly into protein complexes.
(3) How many proteins are only induced over time without any impact of TTP treatment?
Other ARTs appear more promiscuous, e.g. mouse ART2, which ADP-ribosylates many proteins, albeit only at arginine residues (Fig. 2, lane 1).
Many proteins have only one single TM helix (47%) and while some of these TM regions seem to have a primary role to simply anchor the protein to the membrane, that is, no signal or substrate is relying on the TM helices to cross the membrane, several form oligomers that can participate in the signal process.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com