DNA is intimately associated with many proteins, including transcription factors and the histones around which it is packaged.
This is a severe limitation as many proteins, including cytokines, growth factors, enzymes, and receptors have molecular weights exceeding 25 kDa.
Transcriptional regulation is directly enacted by the interactions between DNA and many proteins, including transcription factors, nucleosomes, and polymerases.
Transcriptional regulation is directly enacted by the interactions between DNA and many proteins, including transcription factors (TFs), nucleosomes and polymerases.
Previous studies also showed that expression of a dominant negative fragment of beta-arrestin-1 reduces PAR-2-stimulated internalization, ERK1/2 activation, and cell migration; however, this reagent may block association of many proteins, including beta-arrestin-2 with clathrin-coated pits.
PolyP forms complexes and modulates activities of many proteins including ion channels.
Many proteins including p53 are known to be glutathionylated and regulated by redox [39], [40].
Within the pericentriolar matrix, many proteins including Cnn assemble into a scaffold that docks the γ-tubulin ring complex, which nucleates and controls microtubule growth [16].
Cerebral insults initiate changes in expression of many proteins, including interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNFα), and the 70-kDa heat shock protein (HSP70).
Previous studies on Hsp90α and MMP-2 activation were preformed with conditioned media, which contains many proteins including active MMP-2.
These peptides conform to a general motif of 4 key residues that is found in many proteins, including all previously reported substrates.
