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Many protein interaction data sets were cross-validated with human gene co-expression profiles such as [ 40].
OPN has many protein interaction domains which are thought to play a role in the function of the protein.
As the structure of PSD95 includes many protein interaction domains three PDZ, a single SH3 and a single GK domain it is possible that each domain controls specific behaviours by recruiting specific protein-binding partners.
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However, when interactions between the TAPs and all Plasmodium proteins were examined, far too many protein interactions were observed.
The RecQ C-terminal (RQC) domain of WRN, containing α2-α3 loop and β-wing motifs, is important for DNA binding and for many protein interactions.
For proteins that interact with muscarinic receptor, Borroto-Escuela et al. [ 84] revealed many protein interactions in various signaling pathways that will allow a better understanding of the muscarinic interactome.
While HTP methods can help to identify many protein interactions, their overlap is usually low, and even when combined were shown to result in a false negative rate of around 41% (Braun et al. 2009).
Proteins in the same pathway have been found to be present or absent in a genome as a group (Kelly et al., 2003; Pellegrini et al., 1999), and many protein interactions in the yeast network have also been identified for the corresponding protein orthologs in worm (Matthews et al., 2001).
Interactions have been utilised to build many protein-protein interaction network databases, such as DIP [ 13], HPRD [ 14], BIND [ 15], BioGRID [ 16], IntAct [ 17], and MINT [ 18], yielding more than 150,000 binary interactions.
Since Lrig proteins have highly conserved extracellular domains with many protein-protein interaction motifs, a better understanding of the nature and variety of bona fide binding partners will provide important insights into Lrig function.
Paxillin contains many protein-protein interaction domains: five LD motives (Leucine-rich domains) in the amino-terminal part and four LIM domains (double zinc fingers) in the carboxy-terminal part.
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