Exact(4)
Because of the emphasis on the protection of children and young people, Institutional Research Boards (IRBs) often insist that many protective mechanisms are built into interventional medicinal trials, and research that involves more than a small amount of risk tends to be rejected.
To survive short periods of amino-acid starvation, the cell has developed many protective mechanisms.
The majority of molecular studies of plant stress tolerance have been performed with Arabidopsis thaliana, although it is not an extremophile and can therefore be expected to lack many protective mechanisms required to survive extreme environmental conditions.
As indicated in previous studies, donepezil neuroprotective effects might be mediated by many protective mechanisms, such as nAChR upregulation and activation of the nAChR/PI3K pathway [ 8, 15, 17] and the σ1 receptor/PLC/PKC pathway [ 12, 13].
Similar(54)
Cells possess many different protective mechanisms to combat the acute detrimental effects of oxidative stress; however, chronically elevated stress can induce local pathological changes which may be irreversible.
Many bacteria have advanced protective mechanisms for the detoxification of heavy metal ions [ 10].
Here, this paradox is traced to the decline of multiple protective mechanisms at many length scales from nanometres to that of the whole femur.
Thus, mammalian Hsp72 appears to be an attractive target in therapeutic strategies designed to stimulate endogenous protective mechanisms against many deleterious consequences of septic shock by accelerating the functional recovery of susceptible organs in humans [ 40, 90].
Many studies have shown that protective mechanisms of EA pretreatment may involve a series of regulatory molecular pathways including enhanced antioxidant activity [ 8], regulation of the endocannabinoid system [ 12], and involvement of the postreceptor signaling pathway [ 13].
But in sub-Saharan Africa many communities do not have these protective mechanisms in place, and will be particularly vulnerable to the impact of climate change.
There are many aspects to chemotherapy resistance with protective mechanisms operating at each stage of the cytotoxic process.
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